MedTrace Logo

Genomic Basis of Neurodevelopmental and Brain Outcomes in Congenital Heart Disease (CHD Brain and Genes)

NCT03070197 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 196

Last updated 2020-08-13

No results posted yet for this study

Summary

Approximately 400 Congenital heart disease patients will participate in the research study which will include one or more research visits for neurodevelopmental testing, brain MRI, and collection of medical history including previously collected genetic sequencing results. The investigators will explore the association between genetic variants, neurodevelopmental deficits, and brain MRI endophenotype. Analyses will compare groups with and without deleterious de novo mutations.

Conditions

  • Heart Disease Congenital

Interventions

OTHER

Exposure of interest: Brain MRI

Brain MRI will be conducted in all participants

OTHER

Exposure of interest: neurodevelopmental assessments

neurodevelopmental testing will be conducted in all participants.

Sponsors & Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

  • Children's Hospital Medical Center, Cincinnati

    lead OTHER

Principal Investigators

  • Jane Newburger, MD · Boston Children's Hospital

Eligibility

Min Age
8 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-09-18
Primary Completion
2020-06-29
Completion
2020-06-29

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03070197 on ClinicalTrials.gov