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Changes in the Microenvironment of HPV-induced Head and Neck Cancers in West Indies and Metropolitan Population

NCT03580070 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 140

Last updated 2020-02-17

No results posted yet for this study

Summary

Retrospective observational comparative and multicentric study of the microenvironment of HPV-induced head and neck cancers, with comparison between West Indies and Metropolitan populations, and therapeutic implications. This assessment is carried out by in situ multiparametric study with multiple immunofluorescence staining for cluster of differentiation 3, cluster of differentiation 4, cluster of differentiation 8, PROGRAMMED DEATH-1, PROGRAMMED DEATH-L1, PROGRAMMED DEATH-L2, cytokeratin and cluster of differentiation 68 and automated reading. HPV genotypes will be characterized. Learning these techniques will allow me to promote them in West Indies on my way back, and they may be applicable to other HPV-induced cancers.

Conditions

  • Immunotherapy

Interventions

BIOLOGICAL

Immunotherapy

Patients with primitive head and neck squamous cells carcinoma diagnosed on surgical resection or biopsic sample, between 2008 and 2015. They were included when expressing p16 as assessed by immunochemistry and positive HPV DNA by in situ hybridation or positive HPV PCR

Sponsors & Collaborators

  • European Georges Pompidou Hospital

    collaborator OTHER

  • University Hospital Center of Martinique

    lead OTHER

Principal Investigators

  • Vincent MOLINIE, Pr · CHU Martinique

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-12-07
Primary Completion
2019-10-19
Completion
2019-12-31

Countries

  • France
  • Martinique

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03580070 on ClinicalTrials.gov