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Evaluation of Left Bundle Branch Area Pacing As A Rescue Strategy for Cardiac Resynchronization Therapy Non-Response

NCT05884411 · Status: WITHDRAWN · Phase: NA · Type: INTERVENTIONAL

Last updated 2025-08-11

No results posted yet for this study

Summary

This study aims to investigate whether the investigators can improve heart function in patients with heart failure who have undergone cardiac resynchronization therapy, but have not had an improvement in their heart function at least one year after the procedure. The investigators will evaluate whether placing a new pacing lead (electrode) in a different part of the heart may increase heart function and decrease heart failure symptoms.

Conditions

  • Systolic Heart Failure
  • Heart Failure With Reduced Ejection Fraction
  • CRT Non-Response
  • Left Bundle Branch Area Pacing

Interventions

DEVICE

Left bundle branch area pacing

A cardiac pacing electrode is inserted into the left bundle branch area of the myocardium via a transvenous approach.

DIAGNOSTIC_TEST

Cardiac MRI

A diagnostic imaging test using magnetic resonance imaging to evaluate cardiac function.

Sponsors & Collaborators

  • VA Office of Research and Development

    lead FED

Principal Investigators

  • Selma D Carlson, MD · Minneapolis VA Health Care System, Minneapolis, MN

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-04-30
Primary Completion
2025-08-05
Completion
2025-08-05
FDA Device
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05884411 on ClinicalTrials.gov