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Why do People Respond Differently to Resistance Training?

NCT05874986 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 393

Last updated 2025-04-16

No results posted yet for this study

Summary

It is well known that regular resistance training (RT) can have health benefits. However, considerable heterogeneity in RT responses has been observed. The mechanisms underlying an individual's ability to respond to RT are mainly unknown but involve a complex network of genomic and non-genomic factors. The investigators aim to examine heterogeneity in physiological responses to RT while closely monitoring other environmental factors (e.g., physical activity levels, nutrition, sleep, and stress). Participants are healthy sedentary males and females aged 18-50 (n=400). A controlled 12-week RT intervention will be conducted in two separate data collection periods due to our sample size to characterize RT response. Data will be collected before, during, and after the study period by using measurements of muscle size, physical fitness characteristics, and body composition, as well as by collecting blood samples and questionnaires. The investigators will identify the underlying factors contributing to why people differ in their physiological responses to RT. For this, comprehensive background data will be collected to identify common denominators underlying individual differences in response to RT. The investigators will use sophisticated analytical methods to reveal new predictors of training response for different traits. This research project aims to gain insight into the sources of individual variation in physiological responses to RT. On this basis, exercise training can be personalized to optimize the benefits of RT for all individuals. Ultimately, the investigators will also be able to justify better using RT as part of individualized healthcare strategies in the future.

Conditions

  • Exercise Training
  • Healthy
  • Skeletal Muscle Hypertrophy

Interventions

OTHER

Resistance training

12-week resistance training intervention

Sponsors & Collaborators

  • Academy of Finland

    collaborator OTHER

  • University of Jyvaskyla

    lead OTHER

Principal Investigators

  • Juha P Ahtiainen, Assoc.Prof. · University of Jyväskylä, Faculty of Sport and Health Sciences

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-02-22
Primary Completion
2024-08-21
Completion
2024-08-21

Countries

  • Finland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05874986 on ClinicalTrials.gov