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Multicentre Implementation and Validation of a Molecular Diagnostic for VitreoRetinal Lymphoma

NCT05841914 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 220

Last updated 2025-07-23

No results posted yet for this study

Summary

The goal of this observational study is to gain new insights into the changes in proteins, genes and other molecular biological substances in the aqueous humour, vitreous humour, blood serum and, in rare cases, retina/choroid samples in patients with ocular lymphoma disease. The hope is that this will expand the understanding of the mechanisms of the disease and thus contribute to improved and simplified diagnosis and treatment strategies in the future. The aim is the inclusion of at least 220 patients during the study period. The main questions it aims to answer are:

* to evaluate the diagnostic quality of extended molecular diagnostics (based on standard work-up) of vitreous samples for the specific VitreoRetinalLymphoma (a type of ocular lymphoma disease) diagnosis in comparison to standard work-up alone.
* To monitor VRL patients as part of regular tumour follow-up over a period of 24 months to determine the value of biomarkers with regard to treatment response and development of recurrence in the eye. Similarly, the vitritis patients are followed up by telephone every six months for a period of 24 months, during which questions of any interim occurrence of a VRL or other cancerous tumors are asked according to a defined catalogue of questions.

Conditions

  • Vitreoretinal Lymphoma

Sponsors & Collaborators

  • University Hospital Tuebingen

    collaborator OTHER

  • University Hospital Schleswig-Holstein

    collaborator OTHER

  • Vinodh Kakkassery, MD

    lead OTHER

Principal Investigators

  • Vinodh Kakkassery, PD Dr.med. · University of Luebeck

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-06-01
Primary Completion
2026-09-30
Completion
2028-09-30

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05841914 on ClinicalTrials.gov