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The Usefulness of Antibiotics in Smokers Receiving Dental Implants

NCT05827211 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2023-07-20

No results posted yet for this study

Summary

Objectives: This randomized clinical trial will compare the usefulness of pre- and postoperative antibiotics while strict asepsis will be followed during periodontal surgery in smokers diagnosed with Stage III Grade C Generalized Periodontitis.

Material and Methods: Two groups of 40 consecutive patients each with fully or partially edentulous jaws will be enrolled. Antibiotics group (GrAB+): will receive oral doxycycline 200 mg, 1 h pre-operatively and 100 mg g for 9 days post-operatively. Non-antibiotics group (GrAB- ): will receive a placebo (no antibiotics). Bacterial samples will be taken from the peri-oral skin before and at the end of the surgery. In 12 patients in each group, samples will also be taken from the nares. A visual analogue scale will evaluate symptoms of infection/ inflammation by both the patient and the periodontist at suture removal.

Conditions

  • Dental Implant Therapy

Interventions

PROCEDURE

Antibiotic group

Partially or fully edentulous smoker patients will be treated by dental implants and will receive systemic antibiotics

PROCEDURE

Non-Antibiotic group

Partially or fully edentulous smoker patients will be treated by dental implants and will receive placebo

Sponsors & Collaborators

  • Arab American University (Palestine)

    lead OTHER

Principal Investigators

  • Mahmoud Abu-Ta'a · Department of Dental sciences, Faculty of Graduate Studies, Arab American University (AAUP)

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
19 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-04-02
Primary Completion
2023-04-30
Completion
2023-06-10

Countries

  • Palestinian Territories

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05827211 on ClinicalTrials.gov