MedTrace Logo

Impact of Antibiotic Treatment and Extraction on the Oral Micro Biome

NCT02951676 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 67

Last updated 2017-10-26

No results posted yet for this study

Summary

This is a prospective, longitudinal, observational, cohort study investigating young adults undergoing surgical extraction of a wisdom tooth with and without antibiotics post-operatively. The prescription of antibiotics will be based on clinical judgment based on case complexity, trauma and length of procedure. No randomization will be performed. Saliva will be collected at seven observational time points ( Baseline, one week ,two weeks, three weeks , one month,three months and six months.) and Supragingival plaque samples will be collected at four observational time points ( Baseline , one week , one month, and 3 months) .A control group of 15 subjects who do not undergo dental extractions or antibiotic treatment will be recruited after obtaining informed consent and will be followed up for the same seven time points..Routine standard care will be observed. No new medications are triedThe samples will be analysed for identification of bacterial genes using 16 S r RNA gene sequecing and QPCR for change in the antibiotic resistance genes overtime. Kindly note that in the current study the participants are patients who are already scheduled to undergo tooth extractions with or without antibiotic treatment based on clinical judgement by the clinician performing the extraction. ( These patients are on the waiting list for third molar extractions in the dental hospital concerned.)

The participants will receive the intervention( Third molar extraction with /without antibiotics) in the same manner and intensity even if they are not enrolled for the study.

Conditions

  • Impacted Third Molar Tooth

Interventions

PROCEDURE

Extraction

Extraction of impacted third molar teeth

Sponsors & Collaborators

  • The University of Hong Kong

    lead OTHER

Principal Investigators

  • Michael G Botelho, BDS,MsC,PhD · Faculty of Dentistry, The University of Hong Kong

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-12-31
Primary Completion
2018-03-31
Completion
2018-06-30

Countries

  • China

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02951676 on ClinicalTrials.gov