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Amoxicillin to Prevent Bacteria and Inflammatory Biomarkers After Intensive Periodontal Therapy

NCT03354338 · Status: UNKNOWN · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 90

Last updated 2017-11-27

No results posted yet for this study

Summary

There are not published studies evaluating the incidence, nature, magnitude and/or duration of bacteremia after periodontal treatment. The pre-surgical antibiotics have been studied particullary over Gram positive bacterial but not over gram negative bacterial and their secondary effects over the systemic pro-inflamation. Objective: to evaluate the efficacy of intensive periodontal therapy and pre-medication with oral amoxicilline on inflammatory bio-markers and the incidence, duration and magnitude of bacteremia in patients with chronic periodontitis.

Conditions

  • Chronic Periodontitis
  • Bacteremia

Interventions

DRUG

Amoxicillin

Intensive Periodontal treatment; Pre-medication with 2 gr of oral Amoxicillin 1 hour before treatment

OTHER

Placebo

Intensive Periodontal treatment; Pre-medication with 2 gr of Placebo 1 hour before treatment

Sponsors & Collaborators

  • Universidad El Bosque, Bogotá

    lead OTHER

Principal Investigators

  • Luis Antonio Noriega Frontado, MSc (c) · El Bosque University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-09-21
Primary Completion
2018-04-30
Completion
2018-07-31

Countries

  • Colombia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03354338 on ClinicalTrials.gov