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Sympathetic and Vascular Function in Takotsubo Syndrome

NCT05768542 · Status: COMPLETED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 31

Last updated 2023-03-14

No results posted yet for this study

Summary

The primary objective of this prospective, observational study is to compare muscle sympathetic nerve activity at rest and during stress between female patients with Takotsubo syndrome and healthy, matched volunteers.

* Do Takotsubo patients have an increased sympathetic nerve activity compared to controls?
* Do Takotsubo patients have an exaggerated sympathetic nerve activity response to stress?
* Does the sympathetic nerve activity response to stress in Takotsubo change after receiving the beta blocking agent metoprolol?

Participants will be examined with muscle sympathetic nerve activity recording in the peroneal nerve at rest and during cold pressor test. After intravenous injection with beta blocking agent (metoprolol) or placebo (saline) in a 1:1 randomized fashion, muscle sympathetic nerve recording at rest and during stress will be repeated.

Conditions

  • Takotsubo Cardiomyopathy

Interventions

DRUG

Metoprolol Injection

If heart rate below 60, give 5 mg IV. If heart rate above 60, give 5 mg IV and repeat until heart rate below 65 or 20 mg given in total or systolic blood pressure below 110 mmHg.

DRUG

Saline

5 ml given IV

Sponsors & Collaborators

  • Danderyd Hospital

    lead OTHER

Principal Investigators

  • Jonas 9, MD, PhD · Danderyd University Hospital and karolinska Institutet

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
80 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-04-12
Primary Completion
2022-03-23
Completion
2023-01-23

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05768542 on ClinicalTrials.gov