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Pathophysiology of Orthostatic Intolerance

NCT00608725 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 260

Last updated 2025-10-08

No results posted yet for this study

Summary

The purpose of this study is to describe the mechanism of orthostatic intolerance, relying on cardiovascular physiological studies. The syndrome is of undetermined etiology, but the syndrome causes impairment of a number of young adults, females more than males, with symptoms of tachycardia, fatigue, lightheadedness, palpitations, blurred vision, chest discomfort, difficulty concentrating, and dizziness with the upright posture. It is believed that many different pathophysiological processes can give rise to this disorder.

Conditions

  • Tachycardia
  • Postural Orthostatic Tachycardia Syndrome

Interventions

RADIATION

DAXOR

131-I-Human Serum Albumin Blood Volume Assessment Kit

PROCEDURE

QSweat

Quantitative Sweat Testing

DRUG

Intrinsic Heart Rate

Atropine 0.04 mg/kg IV in divided doses Propranolol 0.2 mg/kg IV in divided doses

Sponsors & Collaborators

  • Satish R. Raj

    lead OTHER

Principal Investigators

  • David Robertson, MD · Vanderbilt University

Study Design

Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
1996-12-31
Primary Completion
2029-12-31
Completion
2029-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00608725 on ClinicalTrials.gov