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POTS Adrenergic Ab (CIHR Aims #1&2)

NCT02673996 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 125

Last updated 2026-05-05

No results posted yet for this study

Summary

Objective: In this pilot study, we will test the hypothesis that patients with POTS (age 18-60 years) will have a higher percentage of functional antibodies to adrenergic receptors compared with control subjects without POTS.

Conditions

  • Postural Tachycardia Syndrome

Interventions

DRUG

Phenylephrine

incremental small doses of IV phenylephrine to find the dose that transiently raises systolic blood pressure by 25 mmHg

DRUG

Isoproterenol

incremental small doses of IV isoproterenol to find the dose that transiently raises heart rate by 25 bpm

Sponsors & Collaborators

  • University of Calgary

    lead OTHER

Principal Investigators

  • Satish R Raj, MD, MSCI · University of Calgary

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-01-31
Primary Completion
2029-12-31
Completion
2030-12-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02673996 on ClinicalTrials.gov