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The Metabolic Effects of β-hydroxybutyrate on Working Skeletal Muscle

NCT05732909 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 25

Last updated 2026-03-06

No results posted yet for this study

Summary

The goal of this clinical trial is to test ketone bodies in healthy elderly and young individuals. The main question it aims to answer are:

• Do ketone bodies improve skeletal muscle function?

Participants will ingest a ketone monoester and skeletal muscle function will then be evaluated by:

* Special magnetic imaging techniques
* Intravenous infusion of tracer-marked nutrients
* Performance tests on a ergometer bike and in a dynamometer

Researchers will compare the outcomes between within the young and elderly groups and between the young and the elderly group to investigate if age has an effect on the outcomes.

Conditions

  • Aging
  • Metabolism Disorder
  • Ketonemia
  • Muscle Disorder

Interventions

DIETARY_SUPPLEMENT

D-β-hydroxybutyrate/D 1,3 butanediol monoester

Ketone monoester

Sponsors & Collaborators

  • Danish Diabetes Academy

    collaborator OTHER

  • AP Moeller Foundation

    collaborator OTHER

  • Aarhus University Hospital

    collaborator OTHER

  • Novo Nordisk A/S

    collaborator INDUSTRY

  • University of Aarhus

    lead OTHER

Principal Investigators

  • Niels Jessen, Professor · Aarhus University Hospital

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
20 Years
Max Age
85 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-12-22
Primary Completion
2024-01-10
Completion
2024-01-10

Countries

  • Denmark

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05732909 on ClinicalTrials.gov