Pain Informed Movement for People With Knee Osteoarthritis

Summary

The goal of this clinical trial is to compare a pain informed movement program to standard neuromuscular exercise in people with knee osteoarthritis. The main question it aims to answer are:

1. Are the two interventions a) pain informed movement program plus pain neuroscience education and b) neuromuscular exercise plus standard osteoarthritis education feasible in terms of recruitment, treatment adherence, timelines, data collection procedures, patient follow-up, and resources required?
2. Is there a difference in patient's satisfaction and acceptability of the two programs?
3. Are there any differences in the potential effects of the two programs on subjective pain measures, self-reported function, quality of life, functional leg strength, nervous system pain modulation, brain derived neurotrophic factor and nerve growth factor levels, and psychological factors?

Conditions

• Knee Osteoarthritis

Interventions

OTHER

pain informed movement

group classes twice weekly for 8 weeks of neuromuscular exercise in combination with mind-body techniques such as breath regulation, muscle tension regulation, relaxation, mindfulness, awareness of pain related thoughts and emotions.

OTHER

standard neuromuscular exercise

group classes twice weekly for 8 weeks of neuromuscular exercise.

OTHER

Pain Neuroscience Education (PNE)

The pain neuroscience education (PNE) will be delivered in videos addressing concepts such as the purpose of pain, neurophysiological changes of pain, movement guidelines when pain persists, and self-care techniques to impact neurophysiology and support moving with ease that include breath awareness and regulation, muscle tension regulation, awareness of pain related thoughts and emotions, relaxation, and body awareness.

OTHER

Standard osteoarthritis (OA) education

The standard osteoarthritis (OA) education will address the following topics, OA prevalence, risk factors, symptoms, diagnosis, treatment, role of exercise, surgery, self-management

Sponsors & Collaborators

• Boston University

  collaborator OTHER

• University of Melbourne

  collaborator OTHER

• University of British Columbia

  collaborator OTHER

• McMaster University

  lead OTHER

Principal Investigators

• Lisa Carlesso, PhD · McMaster University

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

40 Years

Max Age

85 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2023-04-03

Primary Completion

2024-12-03

Completion

2024-12-03

Countries

• Canada

Study Locations