EXercise as TReatment for osteoArthritis

Summary

Osteoarthritis (OA) of the knee is a chronic musculoskeletal disease, and a major cause of pain and disability worldwide. Exercise has previously demonstrated good effect in alleviating OA symptoms. However, optimal exercise modes in OA are currently unknown.

This study seeks to evaluate the effects of supplementary focused, knee extensor strength training in addition to neuromuscular exercise (NEMEX) and education in people with OA of the knee as performed in Good Life with osteoArthritis in Denmark (GLA:D ᵀᴹ).

Through a randomized design, study participants will either be allocated to 12 weeks (twice weekly) of NEMEX and education or 12 weeks (twice weekly) of NEMEX and education and focused, knee extensor strength training.

The primary outcome measurement for this study is the Knee injury and Osteoarthritis Outcome Score, subscale Activities of Daily Living (KOOS-ADL), which is a self-reported questionnaire on daily life activities. Other outcomes include parameters of maximal muscle strength and muscle power, muscle imaging, physical function, pain and self-reported health status.

Conditions

• Knee Osteoarthritis

Interventions

OTHER

NEMEX and education + strength training

Optimizing sensorimotor control and achieving functional stability. Increasing knee extensor muscle strength. Teaching everyday disease management.

OTHER

NEMEX and education

Optimizing sensorimotor control and achieving functional stability. Teaching everyday disease management.

Sponsors & Collaborators

• The Danish Rheumatism Association

  collaborator OTHER

• Region Zealand

  collaborator OTHER

• Naestved Hospital

  collaborator OTHER

• University of Southern Denmark

  collaborator OTHER

• Slagelse Hospital

  lead OTHER

Principal Investigators

• Pætur M Holm, PT, MSc · University of Southern Denmark and Department of Physiotherapy and Occupational Therapy, Naestved-Slagelse-Ringsted Hospitals.

• Søren T Skou, PT, PhD · University of Southern Denmark and Naestved-Slagelse-Ringsted Hospitals.

• Henrik M Schøder, MD · Naestved Hospital

• Mathias Wernbom, PT, PhD · Göteborg University

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-07-18

Primary Completion

2019-03-08

Completion

2020-03-31

Countries

• Denmark

Study Locations