Evaluation of Regional Ventilation Distribution in Patients Affected by Abdominal Sepsis After Emergent Laparotomy

Summary

The goal of this clinical trial is to evaluate regional ventilation distribution in patients admitted to the intensive care unit after emergent laparotomy due to abdominal sepsis. The main question it aims to answer is:

• evaluate if patients admitted after an open abdomen strategy have a different regional ventilation distribution compared to patients in which abdomen is closed at the end of the procedure

Participants will undergo non-invasive monitoring (esophageal pressure and electrical impedance tomography) and an blood gas analysis samples.

Researchers will compare open abdomen group and closed abdomen group to see if the ventilation distribution pattern is different.

Conditions

• Abdominal Sepsis
• Acute Respiratory Failure
• Ventilation Therapy; Complications
• Emergencies

Interventions

DIAGNOSTIC_TEST

Arterial blood gas analysis

The researches will collect 2 ml of arterial blood using an arterial line already in place for clinical purposes to perform and arterial gas analysis.

DIAGNOSTIC_TEST

Venous blood gas analysis

The researches will collect 2 ml of arterial blood using a central venous line already in place for clinical purposes to perform a gas analysis.

DIAGNOSTIC_TEST

Esophageal pressure monitoring

The researchers will position an esophageal balloon to evaluate esophageal pressure

DIAGNOSTIC_TEST

Intrabdominal pressure

The researches will assess intrabdominal pressure using the urinary catheter system already in place for clinical purposes .

DIAGNOSTIC_TEST

Electrical impedance tomopgraphy

The researches will evaluate regional ventilation distribution using Electrical impedance tomography at different levels of positive end-expiratory pressure

Sponsors & Collaborators

• University of Milan

  collaborator OTHER

• Università degli Studi di Ferrara

  lead OTHER

Study Design

Allocation

NON_RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

90 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2023-02-15

Primary Completion

2024-05-30

Completion

2024-12-31

Countries

• Italy

Study Locations