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Longitudinal Assessment of Brain Structure and Function in Juvenile-onset Huntington's Disease

NCT05707663 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 37

Last updated 2026-04-30

No results posted yet for this study

Summary

The goal of this observational study is to learn about brain development in Juvenile-onset Huntington's Disease (JoHD). The main questions it aims to answer are:

* Is brain development different in JoHD than Adult-onset Huntington's Disease (AoHD)?
* Can reliable biomarkers for JoHD be found in brain structure and function?

Participants will be asked to complete cognitive tests, behavioral assessments, physical and neurologic evaluation, and MRI. Data collected will be compared to populations who are at-risk for HD and who have been diagnosed with HD as adults.

Conditions

  • Juvenile Huntington Disease
  • Juvenile-Onset Huntington Disease

Sponsors & Collaborators

  • Columbia University

    collaborator OTHER

  • University of California, Davis

    collaborator OTHER

  • The University of Texas Health Science Center, Houston

    collaborator OTHER

  • Children's Hospital of Philadelphia

    collaborator OTHER

  • George-Huntington-Institut GmbH

    collaborator OTHER

  • UCL Queen Square Institute of Neurology

    collaborator OTHER

  • National Institute of Neurological Disorders and Stroke (NINDS)

    collaborator NIH

  • University of Iowa

    lead OTHER

Principal Investigators

  • Peggy C Nopoulos, MD · University of Iowa

Eligibility

Min Age
4 Years
Max Age
30 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-01-01
Primary Completion
2026-08-31
Completion
2026-08-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05707663 on ClinicalTrials.gov