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The Applanation Tonometry in GCA Pilot

NCT05703763 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 146

Last updated 2025-08-07

No results posted yet for this study

Summary

The Applanation Tonometry in Giant Cell Arteritis (ATOM-GCA) study will answer the following questions:

1. How does PWV, measured by applanation tonometry of temporal arteries, differ between patients with and without a final diagnosis of GCA (based on pre-defined criteria 6 months after inclusion)?
2. What is the diagnostic accuracy and positivity cutoff of the PWV, measured by applanation tonometry, in detecting:

1. A clinical diagnosis of GCA (based on pre-defined criteria 6 months after inclusion)?
2. Inflammation of temporal arteries on high-resolution ultrasound?
3. What is the acceptability and adherence of repeat applanation tonometry during the follow-up period in patients with GCA?

Conditions

  • Giant Cell Arteritis

Interventions

DIAGNOSTIC_TEST

Applanation tonometry

Applanation tonometry will be used to measure arterial stiffness in these segments, bilaterally: * Superficial temporal artery to frontal temporal artery * Common carotid artery to superficial temporal artery

DIAGNOSTIC_TEST

Standardized GCA assessment

Clinical assessment, blood test review, high-resolution temporal artery ultrasound using a 24mHz probe.

DIAGNOSTIC_TEST

Repeat applanation tonometry (optional)

Repeat index test at month 6 and at disease relapse.

Sponsors & Collaborators

  • Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal

    lead OTHER

Principal Investigators

  • Jean-Paul Makhzoum · CISSS du Nord-de-l'ile de Montreal

Eligibility

Min Age
50 Years
Max Age
99 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-07-30
Primary Completion
2026-06-30
Completion
2027-07-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05703763 on ClinicalTrials.gov