Genetic Determinants of Kidney Disease in People of African Ancestry With HIV

Summary

Black ethnicity is a major risk factor for chronic kidney disease \[CKD\] in people with HIV infection, suggesting that genetic factors are an important determinant of kidney disease progression in this population. The Gen-Africa study was established in 2018 to allow the study of genetic and clinical risk factors for CKD in people with HIV in the UK. Just over 3000 people across 15 sites were enrolled between May 2018 and January 2020. Demographic and clinical information was collected, and biological samples (buffy coats, plasma and urine) obtained. Cross-sectional analyses have revealed that participants of West-African ancestry are at higher risk of CKD and end-stage kidney disease \[ESKD\], and that genetic variants in the apolipoprotein L1 (APOL1) gene and sickle cell trait (SCT) are predictors of CKD and ESKD. The pathogenesis of APOL1- and SCT-associated CKD is incompletely understood, and additional, longitudinal data will be collected to improve understanding of the contribution of demographic, traditional CKD (diabetes, hypertension, obesity/metabolic syndrome, cardiovascular disease) and HIV (immuno-virological and hepatitis B/C co-infection status, antiretroviral medications) risk factors as well as additional genetic and epigenetic markers.

Conditions

• HIV Nephropathy
• Kidney Injury
• Kidney Diseases
• Diabetes Mellitus
• Obesity
• Cardiovascular Diseases
• Genetic Predisposition to Disease

Sponsors & Collaborators

• Guy's and St Thomas' NHS Foundation Trust

  collaborator OTHER

• Lewisham and Greenwich NHS Trust

  collaborator OTHER_GOV

• Royal Free Hospital NHS Foundation Trust

  collaborator OTHER

• Central and North West London NHS Foundation Trust

  collaborator OTHER

• Barts & The London NHS Trust

  collaborator OTHER

• Chelsea and Westminster NHS Foundation Trust

  collaborator OTHER

• Imperial College Healthcare NHS Trust

  collaborator OTHER

• North Middlesex University Hospital NHS Trust

  collaborator OTHER_GOV

• Brighton and Sussex University Hospitals NHS Trust

  collaborator OTHER

• The Leeds Teaching Hospitals NHS Trust

  collaborator OTHER

• Manchester University NHS Foundation Trust

  collaborator OTHER_GOV

• Newcastle-upon-Tyne Hospitals NHS Trust

  collaborator OTHER

• South Tees Hospitals NHS Foundation Trust

  collaborator OTHER

• Africa Advocacy Foundation

  collaborator UNKNOWN

• Vanderbilt University

  collaborator OTHER

• University of Cape Town

  collaborator OTHER

• University of Pennsylvania

  collaborator OTHER

• Medical Research Council

  collaborator OTHER_GOV

• British HIV Association

  collaborator UNKNOWN

• Gilead Sciences

  collaborator INDUSTRY

• St George's Healthcare NHS Trust

  collaborator OTHER

• Guy's & St Thomas' Charity

  collaborator OTHER

• King's College Hospital NHS Trust

  lead OTHER

Principal Investigators

• Frank A Post · King's College Hospital NHS Trust

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2018-05-01

Primary Completion

2020-01-31

Completion

2030-01-31

Countries

• United Kingdom

Study Locations