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Structural and Functional Grey and White Matter Changes in Patients With Pain Disorders

NCT05679297 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 82

Last updated 2025-01-17

No results posted yet for this study

Summary

The goal of this observational study is to examine the association between exact lesion location and presence of thalamic CPSP (Central post-stroke pain) in a larger number of patients after thalamic stroke.

Conditions

  • Central Post-stroke Pain

Interventions

DIAGNOSTIC_TEST

Quantitative sensory testing (QST)

The QST is a standardized, internationally accepted test battery consisting of several well-established, non-invasive tests, measuring parameters, which reflect nearly all aspects of somatosensation. 1. Thermal detection threshold for the perception of cold, warm and paradoxical heat sensations 2. Thermal pain threshold 3. Mechanical detection thresholds for touch 4. Mechanical pain threshold for pinprick stimuli 5. Stimulus-response functions 6. Wind- up ratio: The wind- up ratio represents the quotient of the pain intensity evoked by 10 pin-prick stimuli and the pain intensity evoked by one single pin-prick stimulus 7. Vibration detection threshold 8. Pressure pain threshold

DIAGNOSTIC_TEST

Magnetic resonance imaging (MRI)

Functional and structural MRI data will be collected using a 3 Tesla Siemens Scanner with a multi-channel head coil. For the resting state functional MRI the subjects will merely lie in the scanner for about 10 minutes. A "painful heat/cold stimulation" will be performed to study the differences in pain processing between the three groups

OTHER

Clinical interview/exam

The pain characteristics will be assessed through a standardized questionnaire. The german pain questionnaire is a validated questionnaire that assesses various dimensions of pain. Patients will also get a complete neurological examination by an experienced clinician.

OTHER

Follow-up interview

Structured telephone interview with 3 Questionnaires 1. The german pain questionnaire 2. Questionnaire regarding clinical development since the last visit designed by the investigators 3. German translation of 12-item-allodynia symptom checklist (ASC-12)

Sponsors & Collaborators

  • European Pain Federation

    collaborator UNKNOWN

  • University Hospital, Basel, Switzerland

    lead OTHER

Principal Investigators

  • Athina Papadopoulou, PD Dr. med. · University Hospital Basel, Department of Neurology

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-05-04
Primary Completion
2024-12-27
Completion
2024-12-27

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05679297 on ClinicalTrials.gov