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Pregabalin Versus Dexmedetomidine for Delirium Prevention After Cardiac Surgery

NCT05640479 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2025-01-07

No results posted yet for this study

Summary

The aim of this study is to compare the effect of perioperative administration of pregabalin versus dexmedetomidine on the prevalence and lasting duration of delirium in elderly patients after cardiac surgery.

Conditions

  • Pregabalin
  • Dexmedetomidine
  • Delirium

Interventions

DRUG

Pregabalin

patients will receive pregabalin capsules (75 mg) will be given 2 h prior to induction of anesthesia and every 12 hours

DRUG

Dexmedetomidine

patients will receive dexmedetomidine after induction of GA a bolus dose of 0.4 μg/kg dexmedetomidine (over a period of 10 to 20 min) followed by an infusion of 0.2 to 0.7 μg/kg/h

Sponsors & Collaborators

  • Tanta University

    lead OTHER

Principal Investigators

  • Doha M Bakr, MD · Lecturer of Anesthesiology

  • Osama M Rehab, MD · Lecturer of Anesthesiology

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-12-15
Primary Completion
2024-12-03
Completion
2025-01-02

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05640479 on ClinicalTrials.gov