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Nutrient Uptake During Continuous Enteral Feeding

NCT05628844 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 20

Last updated 2022-12-02

No results posted yet for this study

Summary

Continuous enteral nutrition is used to feed patients in intensive care who are unable to eat normally. The goal of this observational study is to learn about the uptake of nutrients from feeding formula. The study method will first be applied in healthy persons to establish workability and normal values, then in patients in the intensive care unit to learn how nutrient uptake is affected by critical illness.

The main questions this study aims to answer are:

* what is the time course of uptake of phenylalanine (an amino acid) and glucose (a sugar) from enteral feeding formula given continuously over several hours
* what is the time course of the filling volume of the stomach during continuous enteral feeding

Participants receive feeding formula through a nasogastric feeding tube and blood samples are taken at short intervals to analyse uptake of nutrients into blood. Simultaneously, the filling volume of the stomach is measured by gastric ultrasound.

Conditions

  • Critical Illness

Interventions

PROCEDURE

Continuous enteral feeding

Enteral nutrition by continuous infusion for 10 hrs at a dose corresponding to 25 kcal/kg body weight/day

Sponsors & Collaborators

  • Karolinska University Hospital

    collaborator OTHER

  • Karolinska Institutet

    collaborator OTHER

  • Felix Liebau

    lead OTHER_GOV

Principal Investigators

  • Felix Liebau, MD PhD · Karolinska University Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-01-01
Primary Completion
2026-12-31
Completion
2026-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05628844 on ClinicalTrials.gov