Feasibility, Safety, and Outcomes of Intensive Enteral Nutrition in Patients With Mechanical Ventilation

Summary

Patients with mechanical ventilation are in risk of malnutrition, which could lead to worse outcome. According to guidelines released from authority organizations, enteral nutrition (EN) should be prior approach for critically ill patients. However, initiation and delivery of EN during the early period of ICU admission are frequently hampered, which results in underfeeding. The investigators speculate whether an intensive enteral nutrition strategy could reinforce the delivery of EN thereby improving outcomes. In this multi-center, prospective, randomized parallel clinical trial, the investigators aim to assess the feasibility, safety and outcomes of intensive enteral nutrition in mechanical-ventilated patients.

Conditions

• Critical Illness

Interventions

OTHER

intensive enteral nutrition

After recruitment, patients should be assessed for EN initiation during first 24 hours after ICU admission. 80% of energy target should be reached within 72 hours.

OTHER

routine enteral nutrition

Attendings decide when and how EN should be administered according to guidelines from academic organizations, such as ESPEN or ASPEN.

Sponsors & Collaborators

• Shanghai 6th People's Hospital

  collaborator OTHER

• Shanghai Tongji Hospital, Tongji University School of Medicine

  collaborator OTHER

• Shanghai 10th People's Hospital

  collaborator OTHER

• Shanghai Jinshan Hospital

  collaborator OTHER

• Shanghai Minhang Central Hospital

  collaborator OTHER

• RenJi Hospital

  collaborator OTHER

• Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

  collaborator OTHER

• Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

  collaborator OTHER

• Shanghai East Hospital

  collaborator OTHER

• Xuhui Central Hospital, Shanghai

  collaborator OTHER

• Shanghai Tong Ren Hospital

  collaborator OTHER

• Shanghai Zhongshan Hospital

  lead OTHER

Principal Investigators

• Duming Zhu, doctor · Fudan University

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2016-11-30

Primary Completion

2020-12-31

Completion

2021-06-30

Countries

• China

Study Locations