MedTrace Logo

Effect of Non-invasive Magnetic Stimulation of the Brain on Breathlessness in Healthy Individuals.

NCT05623696 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 21

Last updated 2026-04-29

No results posted yet for this study

Summary

The purpose of this study is to see if the front part of the brain called the "Dorsolateral Prefrontal Cortex" (DLPFC) has a role in our ability to feel breathlessness. The experiment will use a device that sits on the top of the head which produces a magnetic field that penetrates the scalp and excites the brain tissue directly under it. This procedure is called repetitive transcranial magnetic stimulation (rTMS), it is a painless procedure and known to be safe in healthy individuals. Previous research has shown that the pain felt when capsaicin, the active ingredient in 'chilli' powder, is applied to the hand is reduced by applying the rTMS on the scalp directly above the DLPFC part of the brain. In this experiment we want to see if breathlessness is also reduced. We will use a breathing task that will generate a moderate amount of breathlessness by adding a small amount of carbon dioxide to the inhaled air, while preventing the increase in the amount of breathing we would normally see in response to this. If we find that breathlessness produced by this breathing task is reduced after rTMS over the DLPFC, this may lead to new drugs that target this part of the brain in patients suffering from breathlessness due to heart or lung disease. The study will also improve our knowledge of how the brain enables us to feel breathlessness

Conditions

Interventions

DEVICE

rTMS-L-DLPFC

5 Hz rTMS applied using an actual coil over the left DLPFC

DEVICE

rTMS-R-DLPFC

5Hz rTMS applied using actual coil over Right DLPFC

DEVICE

Sham rTMS-DLPFC

5Hz rTMS applied using sham coil over left or right DLPFC

Sponsors & Collaborators

  • University of Oxford

    collaborator OTHER

  • Oxford Brookes University

    lead OTHER

Principal Investigators

  • Shakeeb H Moosavi, PhD · Oxford Brookes University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-02-01
Primary Completion
2024-05-16
Completion
2024-05-16

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05623696 on ClinicalTrials.gov