Cerebellum-Prefrontal Paired-Pulse Stimulation for Methamphetamine Use Disorder

Summary

To investigate the mechanism and efficacy of a novel repetitive transcranial magnetic stimulation (rTMS) intervention model with paired cerebellar-medial prefrontal cortex (mPFC) pulses on methamphetamine use disorder patients and to develop a novel physiotherapeutic intervention to optimise the treatment and management.

Conditions

• Methamphetamine Use Disorder

Interventions

DEVICE

Paired Associative Stimulation Targeting the Cerebellar-mPFC

The protocol consisted of 180 pulse trains. Each train contained 5 pulse pairs delivered over 1 second, resulting in a stimulation frequency of 5 Hz. Within each pulse pair, the cerebellum was stimulated first, followed by the mPFC after a 6-ms inter-stimulus interval (ISI). In total, 900 pulse pairs were administered, and a complete intervention session lasted 11 minutes and 57 seconds.

DEVICE

Sham Intervention over cerebellum and mPFC

The coil will be placed vertically over the cerebellar and mPFC brain regions, allowing participants to perceive the coil's vibration and sound without receiving effective intervention. All other stimulation parameters are identical to those in the active intervention group.

DEVICE

Sham stimulation over the cerebellum + real stimulation over the medial prefrontal cortex

Participants in this group will receive sham stimulation over the cerebellum (The coil will be placed vertically over the cerebellum) combined with real stimulation over the medial prefrontal cortex.

Sponsors & Collaborators

• Chengdu Drug Rehabilitation Center

  collaborator UNKNOWN

• Sichuan Ziyang Compulsory Isolation Drug Rehabilitation Center

  collaborator UNKNOWN

• Mental Health Center, West China Hospital of Sichuan University, Chengdu

  collaborator UNKNOWN

• Wuhan Mental Health Center, The Ninth Clinical School, Tongji Medical College, Huazhong University of Science and Technology, Wuhan

  collaborator UNKNOWN

• HanYang Comoulsory Isolation Drug Rehabilitation Center, Wuhan

  collaborator UNKNOWN

• Shanghai Mental Health Center

  lead OTHER

Principal Investigators

• Min Zhao, PhD · Shanghai Mental Health Center

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

60 Years

Sex

MALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2024-12-24

Primary Completion

2026-07-31

Completion

2026-09-30

Countries

• China

Study Locations