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Studying Nicotine Addiction With Transcranial Magnetic Stimulation

NCT01702948 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 46

Last updated 2019-12-05

No results posted yet for this study

Summary

Background:

\- Nicotine addiction often makes it difficult to stop smoking. Researchers want to understand the areas of the brain that are important in nicotine addiction. They will use a type of brain stimulation called repetitive transcranial magnetic stimulation (rTMS) to look at part of the brain that may be involved in nicotine addiction. They will see how these areas affect brain function, thinking, and decision making. For this study, rTMS will first be tested on nonsmokers, then smokers will be recruited at a later time.

Objectives:

\- To study areas of the brain involved in nicotine addiction.

Eligibility:

\- Individuals at least 18 years of age who do not smoke.

Design:

* Participants will be screened with a physical exam and medical history. They will also provide a urine sample.
* There will be four study sessions. The first session will involve a magnetic resonance imaging (MRI) scan. The other three visits will involve rTMS and MRI scans.
* The first MRI scan will take a baseline picture of the brain. Participants will also practice the tasks for the other three sessions in a mock scanner.
* At the next three visits, participants will have rTMS and MRI scans. Two visits will involve rTMS; the other visit will involve mock rTMS with no actual magnetic stimulation. During the MRI scans, participants will perform tasks that involve decision making.

Conditions

  • Nicotine Dependence

Sponsors & Collaborators

  • National Institute on Drug Abuse (NIDA)

    lead NIH

Principal Investigators

  • Mary R Lee, M.D. · National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-09-10
Completion
2017-10-03

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01702948 on ClinicalTrials.gov