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The Effect of Water Carbonation on Orthostatic Tolerance

NCT05621460 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 25

Last updated 2026-04-23

No results posted yet for this study

Summary

The primary purpose of this investigation is to determine whether water carbonation can improve orthostatic tolerance in healthy control volunteers. Orthostatic tolerance refers to the ability to maintain an adequate blood pressure when standing. In some individuals blood pressure can fall when standing, predisposing to dizzy spells or fainting episodes. Drinking water can boost blood pressure and making fainting episodes less likely. However, it is not clear whether the carbonation of the water has any further impact on the blood pressure response. This is important because it may be that carbonated water expands the stomach (gastric distension), provoking an increase in sympathetic activity. The increase in sympathetic nervous system activity boosts blood pressure. Resolving this question would have important implications for patients with syncope. This study will test whether carbonated water will have any further impact on blood pressure than the already known effect of non-carbonated water.

Conditions

  • Orthostatic Hypotension
  • Syncope
  • Vasovagal Syncope

Interventions

OTHER

500mL carbonated water

Drink 500mL carbonated water immediately prior to head-up tilt test

OTHER

500mL still water

Drink 500mL still water immediately prior to head-up tilt test

OTHER

50mL still water

Drink 50mL still water immediately prior to head-up tilt test

Sponsors & Collaborators

  • Simon Fraser University

    lead OTHER

Principal Investigators

  • Victoria E Claydon, PhD · Professor, Biomedical Physiology and Kinesiology

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
19 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-09-01
Primary Completion
2027-04-30
Completion
2027-04-30

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05621460 on ClinicalTrials.gov