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The Effects of Human Endotoxemia on Functional Capacity of Hematopoietic Stem and Progenitor Cells

NCT05570643 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2022-10-06

No results posted yet for this study

Summary

We will investigate whether human endotoxemia induces changes in human bone marrow cells and their downstream effector cells. To comprehensively investigate underlying mechanisms behind functional and transcriptional changes in these cell types, we will use state-of-the-art systems biology techniques, including single cell transcriptomics (epi)genetics, and metabolomics.

Conditions

  • Sepsis, Endotoxemia, Immunosuppression

Interventions

DRUG

LPS

This is a non-investigational product. LPS is used as challenge agent to achieve a controlled inflammatory state.

DRUG

Placebo

Injection of NaCl 0.9%.

Sponsors & Collaborators

  • UMC Utrecht

    collaborator OTHER

  • Radboud University Medical Center

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-01-05
Primary Completion
2018-06-28
Completion
2018-06-28

Countries

  • Netherlands

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05570643 on ClinicalTrials.gov