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CHILD (Child Health and Infection With Low Density) Malaria

NCT05567016 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 600

Last updated 2026-01-29

No results posted yet for this study

Summary

This trial will assess the long-term health and socioeconomic impact of interventions targeting low-density malaria infection (LMI) among children in Tanzania

Conditions

Interventions

OTHER

Active case detection using molecular testing (ACDm)

In the ACDm arm, children will receive ACD using RDT and qPCR 3x yearly with treatment using artemether-lumefantrine (AL) if RDT or qPCR positive. With fevers, participants will receive standard PCD using RDT.

OTHER

Passive case detection using molecular testing (PCDm)

With fevers, participants will receive PCDm, in which qPCR will be done in RDT negatives with treatment using AL if positive.

OTHER

Control (standard of care)

With fevers, participants will receive standard PCD using RDT with treatment using AL if positive.

Sponsors & Collaborators

  • National Institute of Allergy and Infectious Diseases (NIAID)

    collaborator NIH

  • Ifakara Health Institute

    collaborator OTHER

  • Swiss Tropical & Public Health Institute

    collaborator OTHER

  • Stanford University

    collaborator OTHER

  • Chan Zuckerberg Biohub

    collaborator OTHER

  • University of California, San Francisco

    lead OTHER

Principal Investigators

  • Michelle Hsiang, MD, MSc · University of California, San Francisco

  • Ally Olotu, MD, PhD · Ifakara Health Institute

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
6 Months
Max Age
10 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-07-18
Primary Completion
2025-11-28
Completion
2025-11-28

Countries

  • Tanzania

Study Locations

More Related Trials

Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05567016 on ClinicalTrials.gov