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Early Childhood Malaria Prevention With Maloprim in The Gambia

NCT00294580 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 2253

Last updated 2023-10-03

No results posted yet for this study

Summary

A trial was conducted in the 1980s to compare two strategies for control of malaria in young children aged 3-59 months: treatment with chloroquine versus treatment combined with fortnightly chemoprophylaxis with Maloprim. The impact on mortality and morbidity was assessed at the time, and their cognitive abilities and educational outcomes were assess 14 years later in 2001. The hypothesis was that the chemoprophylaxis would reduce morbidity and mortality and would improve cognitive abilities and educational outcomes in the long term

Conditions

Interventions

DRUG

Maloprim

Sponsors & Collaborators

  • Medical Research Council Unit, The Gambia

    collaborator OTHER

  • Government of the Gambia

    collaborator UNKNOWN

  • London School of Hygiene and Tropical Medicine

    collaborator OTHER

  • Partnership for Child Development

    collaborator UNKNOWN

  • Wellcome Trust

    collaborator OTHER

  • Imperial College London

    lead OTHER

Principal Investigators

  • Brian M Greenwood, MD · London School of Hygiene and Tropical Medicine

  • Matthew CH Jukes, DPhil · Imperial College London

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
SINGLE_GROUP

Eligibility

Min Age
3 Months
Max Age
59 Months
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
1982-04-30
Completion
2001-09-30

Countries

  • The Gambia

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00294580 on ClinicalTrials.gov