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Vocal Cord Responses During Hyperventilation in Normal Individuals and in Mild and Severe Asthmatics.

NCT05565430 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 24

Last updated 2025-05-08

No results posted yet for this study

Summary

The Investigators aim to:

1. Study the effect of hyperventilation on the development of paradoxical vocal cord movement (PVCM) in healthy individuals and in patients with mild and severe asthma,
2. Relate PVCM to airway symptoms and measurements of intra- and extra-thoracic airway hyperresponsiveness (ET-AHR),
3. Evaluate the effects of inhaled anti-cholinergic agents on PVCM induced by hyperventilation.

Hypotheses:

1. In health PVCM will not occur in response to hyperventilation,
2. In asthma PVCM will occur in response to hyperventilation,
3. Airway symptoms and ET-AHR will develop in parallel with PVCM,
4. Inhaled anticholinergic agents will prevent PVCM induced by hyperventilation.

Conditions

  • Hyperventilation
  • Larynx
  • Asthma

Interventions

OTHER

Acute Hyperventilation

Laryngoscopy to assess vocal cord function during acute hyperventilation in normal subjects and asthmatics.

OTHER

Chronic hyperventilation

Laryngoscopy to assess vocal cord function during acute hyperventilation in normal subjects and asthmatics.

DRUG

Effects of anticholinergic medication

Laryngoscopy to assess vocal cord function after administration of anticholinergic medication.

Sponsors & Collaborators

  • Monash Medical Centre

    lead OTHER

Principal Investigators

  • Laurence Ruane, BSc · Monash Health and Monash University

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-06-01
Primary Completion
2025-02-10
Completion
2025-02-10

Countries

  • Australia

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05565430 on ClinicalTrials.gov