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Prognostic Assessment of Diastolic and Systolic Left Ventricular Function in Septic Shock

NCT02918214 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 440

Last updated 2026-03-19

No results posted yet for this study

Summary

Sepsis induces a reversible systolic and diastolic cardiac dysfunction. The presence of a left ventricular (LV) diastolic dysfunction during septic shock could favor harmful volume overload. Recently, a meta-analysis suggested a negative prognostic role of LV diastolic dysfunction in septic patients (Od Ratio: 1.82; 95%CI: 1.12 - 2.97; p = 0.02) but its external validity is hampered by the numerous limits and the heterogeneity of the studies. To date, a pathophysiological link between LV diastolic dysfunction associated with septic shock and the water balance (reflecting volume overload) remains to establish. In addition, small size studies reported an excess of mortality in patients with septic shock who were diagnosed with a high cardiac output. However, no large cohort has yet confirmed the negative prognostic role of a hyperkinetic hemodynamic profile at the initial phase of septic shock.

Conditions

  • Septic Shock
  • Echocardiography
  • Diastolic Dysfunction
  • Hyperkinesia

Sponsors & Collaborators

  • University Hospital, Tours

    collaborator OTHER

  • University Hospital, Limoges

    lead OTHER

Principal Investigators

  • Marine GOUDELIN, MD · University Hospital, Limoges

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-01-31
Primary Completion
2019-10-31
Completion
2019-10-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02918214 on ClinicalTrials.gov