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Acute Plasma Abeta Responses to Stress

NCT05521919 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 38

Last updated 2025-12-10

No results posted yet for this study

Summary

Research has shown that activation of the sympathetic nervous system for extended periods or during certain times in life can increase the risk for Alzheimer's disease. Some research in animal models show that acute activation of the sympathetic nervous system through stress exposure can increase certain Alzheimer's disease-related biomarkers, such as amyloid-beta, within hours of exposure. However, how acute sympathetic nervous system activation via stress exposure affects amyloid-beta levels in humans has yet to be examined.

In this study, the investigators will examine whether brief increases in sympathetic activation result in immediate changes in plasma amyloid-beta levels in the five hours after exposure.

Conditions

  • Stress Reaction
  • Stress Physiology

Interventions

BEHAVIORAL

Sympathetic Nervous System Activation

Participants will complete a task that increases sympathetic nervous system activation.

BEHAVIORAL

No-stress

Participants will complete a task that will not affect their sympathetic nervous system activity.

Sponsors & Collaborators

  • Washington University School of Medicine

    collaborator OTHER

  • Keck School of Medicine of USC

    collaborator OTHER

  • University of Southern California

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-12-05
Primary Completion
2024-12-10
Completion
2024-12-10

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05521919 on ClinicalTrials.gov