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Autonomic Nervous System and Nitric Oxide Interactions

NCT01137253 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 21

Last updated 2018-02-28

No results posted yet for this study

Summary

The investigators are interested in the role of the autonomic nervous system in the regulation of endothelial function among obese hypertensive subjects. In particular, the investigators will study how endothelial function (response to intra-arterial acetylcholine) changes during autonomic withdrawal.

Conditions

  • Endothelial Dysfunction

Interventions

DRUG

Trimethaphan

Trimethaphan 4 mg/min IV, for the duration of the study (approximately 2 hours)

DRUG

Placebo

Response to intrabrachial vasodilators during IV saline infusion

Sponsors & Collaborators

  • Vanderbilt University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-06-30
Primary Completion
2017-01-31
Completion
2017-01-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01137253 on ClinicalTrials.gov