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Effect of Omega-3 Fatty Acids on Kynurenine Metabolism and Mood

NCT05520437 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2022-08-30

No results posted yet for this study

Summary

The purpose of the current study is to explore the effect of omega-3 fatty acids supplementation on stress-induced changes to kynurenine metabolism and mood.

The objectives of this research project are as follows:

1. To compare biochemical parameters (KYN and KYNA, markers of oxidative stress, and markers of inflammation) between physically active and inactive males
2. To determine the impact of a 3-month supplementation with omega-3 fatty acids on mood, inflammation markers and oxidative stress, and changes in KYN and KYNA
3. To determine the impact of the stress manipulation test (TSST) on mood and changes in KYN and KYNA before and after the omega-3 fatty acids supplementation

Conditions

  • Stress-induced Mood
  • Kynurenine Pathway and Its Metabolites

Interventions

DIETARY_SUPPLEMENT

Omega-3 fatty acids

Participants received Omega-3 supplements (NAMEDSPORT) in the form of softgels over a period of 12 weeks. The supplement is certified by the International Fish Oil Standards™ (IFOS™) Program. Daily dose contained a total of 3276 mg of Omega 3 (4000 mg of fish oil of which: EPA 2234mg; DHA 916mg).

DIETARY_SUPPLEMENT

Placebo

Participants will receive a placebo in the form of MCT oil capsules with no effect on the hypothesized outcome.

Sponsors & Collaborators

  • National Science Centre, Poland

    collaborator OTHER_GOV

  • Medical University of Gdansk

    lead OTHER

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
28 Years
Max Age
48 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-11-20
Primary Completion
2022-12-31
Completion
2023-02-28

Countries

  • Poland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05520437 on ClinicalTrials.gov