Researchers at MD Anderson developed an extracellular vesicle-based platform that delivers full-length DMD mRNA, restoring dystrophin production and improving muscle function in preclinical Duchenne muscular dystrophy models. The study, published in Nature Biomedical Engineering, showed reduced side effects compared with viral gene therapies.
A $9 million grant from ASAP and The Michael J. Fox Foundation funds an Indiana University-led study on immune cell exhaustion in Parkinson's disease, aiming to develop personalized immunotherapies. The multi-institutional team will map immune system changes to uncover biomarkers and explain disease heterogeneity. Advances in proteomics are also enabling molecular subtyping and precision medicine across neurological disorders.
Two studies of older adults with type 2 diabetes linked diabetic retinal disease with higher dementia risk. DME and more severe diabetic retinopathy were associated with higher all-cause and vascular dementia risk, but not consistently with Alzheimer’s disease.
Recent studies examine biological factors affecting sleep in older adults, finding connections between inflammatory markers, antioxidant capacity, and sleep quality in aging populations.
A single blood test measuring p-tau217 protein can predict when cognitively unimpaired individuals will develop Alzheimer's symptoms, with a margin of error of 3-4 years, potentially accelerating clinical trials.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07729748 |
Predicting Parkinson's Disease Before It Strikes: A Brain Imaging Study in At-Risk Individual |
ACTIVE_NOT_RECRUITING | |
| NCT07361887 |
Deciphering the Effect of Moderate Wine Consumption on Healthy Aging Through Postprandial Extracellular Vesicles. |
RECRUITING | NA |
| NCT07224490 |
Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease |
RECRUITING | PHASE1 |
| NCT07091396 |
Home Transcranial Direct Current Stimulation (tDCS) to Enhance Functional Recovery |
ACTIVE_NOT_RECRUITING | NA |
| NCT06873750 |
Neuromodulation and fMRI in Neurodegenerative Diseases Study |
NOT_YET_RECRUITING | NA |
| NCT06690983 |
Tau PET/CT in Various Tau-Related Disease Patients |
RECRUITING | |
| NCT06638580 |
Periodontitis Provokes Retinal Neurodegenerative Effects of Metabolic Syndrome: A Cross-Sectional Study |
COMPLETED | |
| NCT06150495 |
Glycemic Control and Retinal Microvascular Changes |
ACTIVE_NOT_RECRUITING | |
| NCT06147596 |
Heading in Football: Impact on Neural Blood Biomarkers |
COMPLETED | |
| NCT06088355 |
Moderate Versus High Volume Light-Moderate Intensity Exercise for People With Moderate Parkinson's Disease |
RECRUITING | NA |
