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Longitudinal Investigation of I2BS in PD

NCT05516719 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 44

Last updated 2025-10-07

No results posted yet for this study

Summary

In this study, the researchers aim to find a biomarker of PD. Using imaging scans called Positron Emission tomography (PET), Single Photon Emission Computed Tomography (SPECT), and Magnetic Resonance Imaging (MRI). The PET and SPECT scans use small amounts of radiation and specific compounds called tracers, to study chemical changes in the brain in a way not possible with any other procedure. The MRI uses magnetic fields to generate images of brain structure and function

Conditions

Interventions

OTHER

Positron Emission Tomography (PET) scan using BU99008 tracer

A positron emission tomography (PET) scan produce detailed 3-dimensional images of the inside of the body by showing radiation from tracers used to highlight specific areas of the brain.

OTHER

FP-CIT Single-photon Emission Computed Tomography (SPECT) scan

A single-photon emission computerized tomography (SPECT) scan allows analysis of brain function by creating 3D Pictures using compounds called tracers.

OTHER

Magnetic Resonance Imaging (MRI) Scan

MRI (magnetic resonance imaging) uses magnets alongside radio waves to create pictures of the brain.

OTHER

Lumbar puncture

A lumbar puncture is where a thin needle is inserted between the bones in your lower spine using local anaesthetic. This allows the collection of Cerebrospinal fluid ( CSF)

Sponsors & Collaborators

  • University of Exeter

    lead OTHER

Principal Investigators

  • Marios Politis, Professor · University of Exeter

Eligibility

Min Age
25 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-11-01
Primary Completion
2026-06-30
Completion
2026-06-30

Countries

  • United Kingdom

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05516719 on ClinicalTrials.gov