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PLGA Nanoparticles Entrapping Ciprofloxacin to Treat E-Fecalis Infections in Endodontics

NCT05475444 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 55

Last updated 2022-07-27

No results posted yet for this study

Summary

PLGA nanoparticles coated with Chitosan polymer were prepared and then incorporated in In -situ gel to be injected to root canals of patients suffered from bacterial infection of their endodontics.

Conditions

  • Bacterial Infections Oral

Interventions

DEVICE

Chitosan Coated PLGA nanoparticles entrapping Ciprofloxacin incorporated in smart gels

antibacterial nanoparticles were used because of their small size, sustained release and positive charge which interact with the negatively charged surface of bacterial cell causing its destruction.

DEVICE

Ciprofloxacin paste and solution

Conventional antibacterial paste and solution were compared to nanoparticles smart gels to treat endodontics bacterial infection

Sponsors & Collaborators

  • British University In Egypt

    lead OTHER

Principal Investigators

  • Mona Arafa, Professor · The British University in Egypt

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-03-01
Primary Completion
2020-03-08
Completion
2020-03-15

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05475444 on ClinicalTrials.gov