Continuation of the nuMoM2b Heart Health Study

Summary

Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in U.S. women at all ages, and large knowledge gaps exist in CVD predictive and preventative strategies for women. The nuMoM2b Heart Health Study (nuMoM2b-HHS) has followed a demographically diverse cohort of women enrolled and richly phenotyped during their first pregnancy, with data and biospecimens prospectively collected for up to 7 years thereafter. The overarching scientific goal of this study is to define the relationship between adverse pregnancy outcomes (APOs) and CVD to optimize CVD prediction, prevention, and treatment strategies for women. Continued follow-up of this observational cohort, building on a foundation of existing high-quality data, biospecimens, and administrative structures with a robust framework for ancillary study development and implementation, provides a unique opportunity to address knowledge gaps regarding the early mechanisms and trajectory of CVD in women.

Conditions

• Cardiovascular Diseases

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI)

  collaborator NIH

• Northwestern University

  collaborator OTHER

• Ohio State University

  collaborator OTHER

• Cedars-Sinai Medical Center

  collaborator OTHER

• Case Western Reserve University

  collaborator OTHER

• Columbia University

  collaborator OTHER

• ChristianaCare

  collaborator OTHER

• Indiana University

  collaborator OTHER

• University of Pittsburgh

  collaborator OTHER

• University of California, Irvine

  collaborator OTHER

• University of Utah

  collaborator OTHER

• University of Pennsylvania

  collaborator OTHER

• Intermountain Health Care, Inc.

  collaborator OTHER

• University of Michigan

  collaborator OTHER

• West Virginia University

  collaborator OTHER

• Old Dominion University

  collaborator OTHER

• RTI International

  lead OTHER

Principal Investigators

• George Saade, MD · Old Dominion University

• Phillip Greenland, MD · Northwestern University

• Rebecca McNeil, PhD · RTI International

Eligibility

Min Age

18 Years

Sex

FEMALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2022-11-29

Primary Completion

2027-01-31

Completion

2027-01-31

Countries

• United States

Study Locations