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Utilizing Augmented Artificial Intelligence for Aminoacidopathies

NCT05437445 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 2081

Last updated 2022-07-05

No results posted yet for this study

Summary

The objective of the study was to interpret metabolic profiles of plasma amino acid (PAA) and compare reference intervals (RI) of PAA data from Pakistan with data from other countries using Clinical Laboratory Integrated Reports (CLIR). One-year data (reference and cases data) of twenty-two PAA, analyzed by ion exchange high performance chromatography at Biochemical Genetics Laboratory (BGL) of Aga Khan University Pakistan, was compiled in a comma-separated values (.csv) file and uploaded on CLIR Software using AAQP (Amino Acid in Plasma) application for statistical analysis. Among total of 2081 PAA profiles, 92% (n=1913) were completely normal with all PAA values falling within the age-specific reference range. A concordance of 98.8% was noted between the reporting done by the BGL at AKU and then after applying CLIR tools.

Conditions

  • Inborn Errors of Metabolism

Interventions

DIAGNOSTIC_TEST

Plasma amino acid assay

Plasma amino acid analysis was performed on all the blood samples received in biogenetics lab at Aga khan university, Karachi during one year period.

Sponsors & Collaborators

  • Aga Khan University Hospital, Pakistan

    lead OTHER

Principal Investigators

  • Dr lena Jafri · Aga khan hospital karachi, Pakistan

Eligibility

Min Age
1 Year
Max Age
16 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-08-01
Primary Completion
2020-08-30
Completion
2020-08-30

Countries

  • Pakistan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05437445 on ClinicalTrials.gov