Silo Pharma received a European patent grant and a Japan patent allowance for SPC-15, its intranasal PTSD prevention candidate. The patents cover methods using serotonin 4 receptor agonists to prevent stress-induced psychiatric disorders.
Insilico Medicine named ISM9528 as its 31st AI-driven preclinical pain candidate, published a target discovery study for a rare sinonasal cancer, and advanced partnerships with MSK and Takeda. The company is also presenting oncology programs at AACR 2026.
Lidocaine patches cut opioid use after radiofrequency ablation for hepatocellular carcinoma; a protocol tests liposomal bupivacaine for mastectomy; a pipeline report profiles 40+ companies.
Grünenthal has successfully completed a Phase I trial for its proprietary nociceptin receptor (NOP) agonist, demonstrating safety and tolerability in 113 healthy volunteers. The company plans to advance the novel pain therapy into a Phase II trial later this year, with results expected in the second half of 2027.
The treatment landscape for multiple myeloma is evolving rapidly with T-cell engaging therapies like bispecific antibodies and CAR T-cell treatments shifting care toward a chronic condition with potential treatment breaks. This evolution is creating new side effect management challenges and complicating clinical trial design as sponsors grapple with selecting comparator arms and adapting to a rapidly shifting standard of care.
Research found women undergoing breast reconstruction after mastectomy have goals extending beyond physical restoration. Newer nerve-preserving techniques aim to restore chest and nipple sensation but are still being studied.
Post-mastectomy pain syndrome affects 10-50% of women after breast removal surgery, causing chronic pain that can last years. The condition lacks consistent diagnosis, standardized screening, and FDA-approved treatments, leaving many patients struggling to find relief. Recent research calls for increased focus on this undertreated complication of breast cancer survival success.
Women with endometriosis face increased long-term risk for thyroid disorders including hypothyroidism and Graves disease, according to a 20-year retrospective study. ACOG released new clinical guidance aimed at reducing diagnostic delays through clinical diagnosis and earlier treatment initiation.
NRx Pharmaceuticals completed an in-person FDA Type C meeting regarding NRX-100, a preservative-free ketamine formulation for suicidal depression. The company received guidance on a path to file a New Drug Application based on existing trial data and Real World Evidence from over 65,000 patients.
New research from Michigan State University reveals that differences in hormone-regulated monocytes explain why women experience longer-lasting chronic pain than men, with males producing more IL-10 to shut down pain signals.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07785648 |
Mindfulness-Based Cognitive Therapy Vs. the Health Enhancement Program for Chronic Pain and Early Cognitive Decline; The Feeling of Being Pilot RCT |
NOT_YET_RECRUITING | NA |
| NCT07783295 |
A Randomized, Triple-Masked, Placebo-Controlled Crossover Trial of Full-Spectrum Cannabis Extract for Chronic Pain and Bone Health Biomarkers in Women |
NOT_YET_RECRUITING | PHASE2 |
| NCT07781982 |
Action Observation and Motor Imagery Training in Cervical Disc Herniation |
NOT_YET_RECRUITING | NA |
| NCT07779733 |
BurstDR Spinal Cord Stimulation Versus Sham in Established Responders |
NOT_YET_RECRUITING | NA |
| NCT07779473 |
Tapentadol vs Tramadol in Arthroscopic Rotator Cuff Repair |
ACTIVE_NOT_RECRUITING | |
| NCT07778381 |
National Survey of Chronic Occupational Pain in Thai Anesthesia Providers |
NOT_YET_RECRUITING | |
| NCT07776600 |
VETERANS AFFAIRS AUGUSTA |
RECRUITING | NA |
| NCT07769619 |
Integrative AI-Based Multiomic and Neurophysiological Profiling of Chronic Pain in Rheumatoid Arthritis |
RECRUITING | |
| NCT07768501 |
S1R Imaging-Based Cryoneurolysis in Chronic Pain |
NOT_YET_RECRUITING | EARLY_PHASE1 |
| NCT07766213 |
Pain Phenotypes in Individuals With Multiple Sclerosis |
NOT_YET_RECRUITING |
