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Understanding Circadian Responses to Light in Persons With Mild Cognitive Impairment

NCT05411822 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 36

Last updated 2025-06-24

Study results available
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Summary

The purpose of this research study is to investigate the relationship between light, the thickness of the pigment at the back of your eye, melatonin levels, and memory. The study will investigate whether changing light distribution pattern from "on-axis"' (i.e., directed along the eye's visual axis to the fovea) to "off-axis" (i.e., directed on the periphery of the eye's visual axis) impact melatonin suppression in 24 mild cognitive impairment participants and 24 healthy, age-matched controls.

Conditions

Interventions

DEVICE

Lighting Intervention Blue light

Custom made lighting fixture that will deliver the blue lighting intervention. Blue light (λmax = 451 nm) on axis and off axis.

DEVICE

Lighting Intervention Green light

Custom made lighting fixture that will deliver the green lighting intervention. Green light (λmax = 522 nm) on and off axis

OTHER

Dim-light control condition

(\< 5 lux at the eye) for 30 min

Sponsors & Collaborators

Principal Investigators

  • Mariana Figueiro, PhD · Icahn School of Medicine

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-06-14
Primary Completion
2024-05-31
Completion
2024-05-31

Countries

  • United States

Study Locations

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Diseases
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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05411822 on ClinicalTrials.gov