Effect of FMD on Colorectal Cancer Patients

Summary

Extensive preclinical evidence suggests that short-term fasting and fasting mimicking diets (FMDs) can protect healthy cells and render cancer cells more vulnerable to chemotherapy and other therapies. However, fasting is difficult for the old and frail subjects.Therefore, FMDs may be more suitable for postoperative dietary intervention in cancer patients. Colorectal tumors have high glucose consumption, which makes tumor cells very sensitive to changes in nutritional metabolism of the surrounding environment (such as diet restriction / fasting). Previous studies have shown that cyclic FMDs are safe and feasible for cancer patients receiving chemotherapy alone. However, the effects of the FMD in patients under radical surgery for colorectal cancer have not been evaluated so far. This study aims to evaluate the impact of FMDs on postoperative recovery and outcomes of patients with colorectal cancer.

Conditions

• Fasting Mimicking Diet
• Colorectal Cancer

Interventions

OTHER

Fasting mimicking diet

The fasting mimicking diet consists of a 5 day regimen: day 1 diet of the diet supplies \~1000 kcal (10% protein, 56% fat, 34% carbohydrate), day 2-5 are identical in formulation and provide 800 kcal (9% protein, 44% fat, 47% carbohydrate). At least 4 cyclic FMDs will be performed after operation.

Sponsors & Collaborators

• Shanghai Cancer Hospital, China

  collaborator OTHER

• Huashan Hospital

  collaborator OTHER

• Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

  collaborator OTHER

• Tongji Hospital

  collaborator OTHER

• Changhai Hospital

  collaborator OTHER

• Shanghai Zhongshan Hospital

  collaborator OTHER

• Fudan University

  lead OTHER

Principal Investigators

• Miaomiao Guo, Dr · Shanghai Zhongshan Hospital

• Meilin Weng, PhD · Shanghai Zhongshan Hospital

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2022-06-08

Primary Completion

2027-10-30

Completion

2027-10-30

Countries

• China

Study Locations