Preoperative Nutritional Status and Postoperative Outcomes in Colorectal Cancer

Summary

The aim of this study was to evaluate the effect of preoperative nutritional status, dietary inflammatory index, and systemic inflammatory response on postoperative outcomes. The study will include 120 colorectal cancer patients who are scheduled for surgical treatment.

Conditions

• Colorectal Cancer

Interventions

DIAGNOSTIC_TEST

Nutrition Risk Screening 2002 (NRS-2002)

Nutritional status assessment tool

DIAGNOSTIC_TEST

Global Leadership Initiative on Malnutrition (GLIM)

Nutritional status assessment tool

OTHER

Measurement of body composition with computed tomography (CT)

The cross section of the third lumbar vertebrae in the CT scan images of the patients will be analyzed for assessment of body composition parameters including skeletal muscle area (SMA), visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT)

DIAGNOSTIC_TEST

Dietary inflammatory index (DII)

The Dietary Inflammatory Index (DII) is a scoring algorithm that indicates the inflammatory potential of the diet.

DIAGNOSTIC_TEST

European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC-QLQ-C30)

Quality of life assessment tool

DIAGNOSTIC_TEST

European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Colorectal Cancer 29 (EORTC-QLQ-CR29)

Quality of life assessment tool

DIAGNOSTIC_TEST

Prognostic Nutritional Index (PNI)

Prognostic Nutritional Index is diagnostic test based on serum albumin level and total lymphocyte count

DIAGNOSTIC_TEST

Neutrophil-Lymphocyte Ratio (NLR)

The neutrophil-to-lymphocyte ratio (NLR) is calculated as the simple ratio between neutrophil and lymphocyte counts.

Sponsors & Collaborators

• Ankara City Hospital Bilkent

  collaborator OTHER

• Hacettepe University

  lead OTHER

Principal Investigators

• Tuba N Yildiz Kopuz · Hacettepe University

• Mehmet Fisunoglu · Hacettepe University

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-07-25

Primary Completion

2022-12-01

Completion

2022-12-01

Countries

• Turkey (Türkiye)

Study Locations