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Multi-level Molecular Profiling of Peak Performance in Endurance Sports

NCT05359744 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2026-02-17

No results posted yet for this study

Summary

Physical activity triggers complex molecular responses, including changes in immune-, stress-, and metabolic pathways. For example, autophagy is essential for energy and cellular homeostasis through protein catabolism, and dysregulation results in compromised proteostasis, reduced exercise performance, and excessive secretion of signaling molecules and inflammatory proteins. However, previous research has been limited by the extend of molecules measured and biological processes covered. A better understanding of these processes through multi-omic analysis can improve knowledge of molecular changes in response to exercise. The main purpose of the investigators study is to analyze the effects of acute exercise in correlation to autophagy and other signaling cascades. Specifically, the investigators plan to perform multi-level molecular profiling in a cohort of healthy male elite cyclists and male and female recreational athletes, before, during, and after a bicycle ergometer test. The results will be compared to a control cohort without intervention.

Conditions

  • Exercise
  • Exercise Test
  • Physical Fitness
  • Healthy

Interventions

DIAGNOSTIC_TEST

Performance testing

Performance testing on a bicycle ergometer.

Sponsors & Collaborators

  • Department of Psychiatry University of Bonn

    collaborator OTHER

  • Paracelsus Medical University

    lead OTHER

Principal Investigators

  • Jens Stepan, MD, PhD · Department of Obstetrics and Gynecology, University Hospital Salzburg, Austria

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-10-15
Primary Completion
2022-08-15
Completion
2022-08-15

Countries

  • Austria

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05359744 on ClinicalTrials.gov