MedTrace Logo

Assessing the Effects of Increased Mitochondrial Function Exercise Training on Muscle Performance

NCT03325491 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 2

Last updated 2019-09-27

No results posted yet for this study

Summary

As people grow older skeletal muscle gradually becomes smaller and weaker, causing reduced mobility and quality of life. To understand and reverse this negative process investigators need to find new ways of improving the ability of muscle to perform physical activity. There is some evidence that supplements may improve how the mitochondria work, and investigators want to explore this idea in more detail. This is possible by measuring how the muscles work and respond to exercise before and after taking the supplement alongside an aerobic (i.e. cycling) and resistance (i.e. weight lifting) exercise programme. This will give us the basic information investigators would need to see if this is a useful idea.

Conditions

  • Impaired Mitochondrial Function, Muscle Performance

Interventions

DIETARY_SUPPLEMENT

Acipimox

Acipimox plus exercise training: Oral supplement containing Acipimox 250mgs as the active ingredient in blinded label tablet form.

DIETARY_SUPPLEMENT

Placebo

Alternate unilateral resistance and aerobic exercise training will also be performed 5 times per week for 6 weeks.

Sponsors & Collaborators

  • Royal Devon and Exeter NHS Foundation Trust

    collaborator OTHER

  • University of Exeter

    lead OTHER

Principal Investigators

  • Colleen Deane, PhD · University of Exeter

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
65 Years
Max Age
75 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-03-07
Primary Completion
2019-09-16
Completion
2019-09-16

Countries

  • United Kingdom

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03325491 on ClinicalTrials.gov