High-Intensity Interval or Concurrent Exercise on Oxidative Stress and Inflammation in Obese Women

Summary

Introduction: Menopause is associated with body composition change, an increase in the cardio-metabolic risk factor for oxidative stress. Nevertheless, it has been suggested that regular physical training is an effective non-pharmacological intervention to reduce oxidative stress and cardio-metabolic disorders in menopausal individuals. Therefore, the present study was conducted to compare the effects of twelve weeks of high-intensity interval training (HIIT) and concurrent (Conc) and on body composition, cardio-metabolic indices and oxidative stress in sedentary obese postmenopausal women.

Materials and methods: Forty-five menopausal obese women voluntarily participated and were randomly assigned into three groups: a) HIIT (6-12×60s of high intensity training (85-95% HRMax) and then running for 60 seconds with low intensity (55-60% HRMax)), b) concurrent endurance (performed on training with 55-75% HRMax) and strength training (including two sets in eight exercise stations with 55-75% 1RM)) and c) control group. Training programs were done for twelve weeks, 3 times per week. Body composition, cardio-metabolic indices and oxidative stress markers were measured before and after twelve weeks of exercise training program.

Conditions

• Women Veterans
• Obese Women
• Postmenopausal
• Sedentary Lifestlye

Interventions

BEHAVIORAL

High-Intensity Interval

HIIT consisted of alternating high- (90-95 % HR\_max) and low-intensity (55-60 % HR\_max) aerobic bouts

BEHAVIORAL

concurrent training

combined aerobic and resistance exercises

BEHAVIORAL

Control Group

usual daily routines

Sponsors & Collaborators

• Sanidad de Castilla y León

  collaborator OTHER

• Ministerio de Ciencia e Innovación, Spain

  collaborator OTHER_GOV

• Fundación General Universidad de Valladolid

  collaborator OTHER

• University of Valladolid

  lead OTHER

Principal Investigators

• Diego F Fernández Lázaro, Vice Dean and Professor · University of Valladolid

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

50 Years

Max Age

65 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2025-09-02

Primary Completion

2025-11-20

Completion

2025-12-08

Countries

• Spain

Study Locations