Yogurt Supplementation to Alter Bone Biomarkers, the Gut Microbiota and Inflammation in Older Adults

Summary

Caribbean Latino adults are a vulnerable population at risk for developing osteoporosis. In addition to lifestyle factors, such as dietary intake, the investigators hypothesize that a unhealthy gut microbial environment coupled with high inflammation contributes to the risk of developing osteoporosis. There has been little research conducted on mechanisms underpinning how a low-intensity dietary intervention, including supplementation with daily yogurt, can affect the gut health of Caribbean Latino adults. The study objectives are to: 1) determine whether daily yogurt supplementation reduces bone turnover (biomarkers of overall bone health) and inflammation compared to a control group that maintains their usual diet (void of yogurt); and 2) collect preliminary data on the effects of daily yogurt supplementation on the gut microbiome compared to diet control group.

Conditions

• Osteoporosis
• Inflammation

Interventions

OTHER

Yogurt Intervention

Participants will be asked to consume one serving of yogurt per day. Nutrient composition of yogurt provided to participants in the yogurt group: Nutrients per serving Serving Size: 141 g Energy (kcal) 170 Total Fat (g) 8 Total Carbohydrate (g) 16 Sugars (g) 15 Protein (g) 5 Sodium (mg) 85 Calcium (%) 15 Vitamin A (%) 4 Ingredients: Pasteurized Grade A Milk, Cane Sugar, Yogurt Cultures (S. thermophilus, L. bulgaricus), Vanilla Extract.

Sponsors & Collaborators

• University of Massachusetts, Worcester

  collaborator OTHER

• The Lawrence Senior Center

  collaborator UNKNOWN

• Danone Institute International

  collaborator OTHER

• American Society for Nutrition

  collaborator OTHER

• The International Osteoporosis Foundation

  collaborator OTHER

• University of Massachusetts, Lowell

  lead OTHER

Principal Investigators

• Kelsey M Mangano, PhD · University of Massachusetts, Lowell

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

50 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2019-03-28

Primary Completion

2020-03-25

Completion

2020-03-25

Countries

• United States

Study Locations