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Effects of Low-Dose Doxycycline on Oral Bone Loss

NCT00066027 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 128

Last updated 2023-09-06

No results posted yet for this study

Summary

The primary purpose of this clinical trial is to determine whether low-dose doxycycline can reduce alveolar bone density loss in postmenopausal osteopenic women with periodontitis and not on hormone replacement therapy (i.e., estrogen deficient).

Conditions

  • Periodontitis

Interventions

DRUG

20 mg doxycycline hyclate

Subjects in the LDD group took 20 mg doxycycline hyclate tablets twice daily for two years

DRUG

Placebo

Subjects in the placebo group took a placebo look-alike twice daily for two years.

Sponsors & Collaborators

  • National Institute of Dental and Craniofacial Research (NIDCR)

    collaborator NIH

  • University of Nebraska

    lead OTHER

Principal Investigators

  • Jeffrey B Payne, DDS · UNMC College of Dentistry

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
45 Years
Max Age
70 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2002-06-01
Primary Completion
2005-10-01
Completion
2005-10-01

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00066027 on ClinicalTrials.gov