MedTrace Logo

Platelets in Cystic Fibrosis Lung Inflammation

NCT05339724 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 53

Last updated 2022-05-20

No results posted yet for this study

Summary

Cystic fibrosis (CF) is a chronic multiorgan disorder caused by mutations in the CFTR (cystic fibrosis transmembrane conductance regulator) gene. Chronic airway infection by bacterial pathogens accounts for the progressive, suppurative pulmonary disease that leads to significant morbidity and mortality in patients with CF. Neutrophil recruitment to the lungs accounts the most important contributor to pulmonary destruction. However, there is evidence that platelets may also have an important role in the pathogenesis of inflammation. To our knowledge, there is few information in platelet levels in patients with cystic fibrosis during pulmonary exacerbation, chronic airway colonization and when stable.

Conditions

  • Platelet Levels and Mean Platelet Volume in Patients With CF

Interventions

OTHER

platelet count and mean platelet volume are obtained from whole blood count

The records of cystic fibrosis patients will be retrospectively evaluated for acute pulmonary exacerbation, chronic airway colonization for bacteria, clinical stable status. PC and MPV will be obtained and matched in 6 groups (described above). Then, PC and MPV will be compared among the groups.

Sponsors & Collaborators

  • Mersin Training and Research Hospital

    lead OTHER_GOV

Principal Investigators

  • Ali Özdemir, MD · Assoc Prof, Mersin City Research & Training Hospital

  • Murat Ersoy, MD · Clinical Pediatrician, Mersin City Research & Training Hospital

Eligibility

Min Age
12 Months
Max Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-04-08
Primary Completion
2022-04-30
Completion
2022-05-01

Countries

  • Turkey (Türkiye)

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05339724 on ClinicalTrials.gov