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Biodistribution of Neutrophile Proteases in the Sputum of Patients Affected by Cystic Fibrosis

NCT00750932 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 52

Last updated 2017-02-27

No results posted yet for this study

Summary

The purpose of the proposed project is to characterize the neutrophile proteases which participate in the chronic inflammatory phenomenon associated with the cystic fibrosis and which are responsible for the degradation of the lung tissue.

The respiratory failure which results from it is one of main causes of the fatal evolution of this pathology but the anti-inflammatory therapies based on the use of antiproteases targeting specifically the soluble elastase did not end, until now, in the hoped results.

The identification of the other noxious targets is a crucial element to give new orientations to the anti-inflammatory strategies based on the administration of antiproteases which remain a promising way.

Conditions

Sponsors & Collaborators

  • University Hospital, Tours

    lead OTHER

Principal Investigators

  • Patrice DIOT, PHD · Tours Hospital

Eligibility

Min Age
6 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-01-31
Primary Completion
2012-01-31
Completion
2012-01-31

Countries

  • France

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00750932 on ClinicalTrials.gov